Wyoming deer killed by Hoosier had CWD
An Indiana hunter will be allowed to keep the head mount of a deer he killed in Wyoming that tested positive for chronic wasting disease.
The unidentified hunter knew about the CWD risk and submitted a portion of the animal to the Wyoming Game and Fish Department for testing before having the meat deboned for transport home. After the animal tested positive for CWD, Wyoming officials contacted the hunter and the Indiana Department of Natural Resources.
Indiana DNR officials disposed of the meat, but the hunter was allowed to keep the mount, according to Dr. Jennifer Strasser, a veterinarian with the Indiana Board of Animal Health and a state conservation officer.
"As long as the skull cap and cape are cleaned properly, the hunter can safely keep the mount," she said.
The Indiana DNR has tight restrictions on transporting deer, elk and other cervids into the state. For information go to www.in.gov/dnr/deerhealth/cwd.htm.
www.courier-journal.com/a...002/SPORTS
stupid is, as stupid does. ...forest gump
From: "Terry S. Singeltary Sr."
Subject: CWD UPDATE 88 AUGUST 31, 2007
lists.ifas.ufl.edu/cgi-bi...&T=0&P=450
Date: Wed, 29 Aug 2007 21:13:08 -0500
From: "Terry S. Singeltary Sr."
Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)
lists.ifas.ufl.edu/cgi-bi...=0&P=26079
Monitoring the Potential Transmission of Chronic Wasting Disease to Humans
Using a Hunter Registry Database in Wyoming (405 lines)
From: Terry S. Singeltary Sr.
Date: Thu, 30 Aug 2007 21:23:42 -0500
lists.ifas.ufl.edu/cgi-bi...S=&P=27654
Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease
creates a new prion strain
Date: August 25, 2007 at 12:42 pm PST
Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease
creates a new prion strain
Date: August 25, 2007 at 12:42 pm PST
J Biol Chem. 2007 Aug 20; : 17709374
Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a
new prion strain.
[My paper] Atsushi Kobayashi , Masahiro Asano , Shirou Mohri , Tetsuyuki
Kitamoto
The genotype (methionine or valine) at polymorphic codon 129 of the human
prion protein (PrP) gene and the type (type 1 or type 2) of abnormal isoform
of PrP (PrP(Sc)) are major determinants of the clinicopathological
phenotypes of sporadic Creutzfeldt-Jakob disease (sCJD). Here we found that
transmission of sCJD prions from a patient with valine homozygosity (129V/V)
and type 2 PrP(Sc) (sCJD-VV2 prions) to mice expressing human PrP with
methionine homozygosity (129M/M) generated unusual PrP(Sc) intermediate in
size between type 1 and type 2. The intermediate type PrP(Sc) was seen in
all examined dura mater graft-associated CJD cases with 129M/M and
plaque-type PrP deposits (p-dCJD). p-dCJD prions and sCJD-VV2 prions
exhibited similar transmissibility and neuropathology, and the identical
type of PrP(Sc) when inoculated into PrP-humanized mice with 129M/M or
129V/V. These findings suggest that p-dCJD could be caused by cross-sequence
transmission of sCJD-VV2 prions.
snip...
In this study, the strain-dependent traits of sCJDMM1
prions were inherited through cross-sequence
transmission without any modification. The
humanized mice with 129V/V produced type 1 PrPres
after inoculation with sCJD-MM1 prions. Because
sCJD-VV1 cases are extremely rare (at most 1-2%
of the total number of sCJD cases) and characterized
by early onset (mean age at onset: 39.3 years) (5),
####################################
our results raise the possibility that CJD cases
classified as VV1 may include cases caused by
iatrogenic transmission of sCJD-MM1 prions or
food-borne infection by type 1 prions from animals,
e.g., chronic wasting disease prions in cervid. In fact,
two CJD-VV1 patients who hunted deer or
consumed venison have been reported (40, 41). The
results of the present study emphasize the need for
traceback studies and careful re-examination of the
biochemical properties of sCJD-VV1 prions.
###################################
In conclusion, cross-sequence transmission of
sCJD-VV2 prions generates a new prion strain with
altered conformational properties and disease
phenotypes as p-dCJD prions. Furthermore, the
newly generated prions have unique transmissibility
including the traceback phenomenon. In the future, if
atypical prion strains emerge through cross-sequence
transmission, especially from animals, traceback
studies will enable us to identify the origin of the
prions.
REFERENCES...snip...end
FULL TEXT ;
www.jbc.org/cgi/content/a...type=HWCIT
lists.ifas.ufl.edu/cgi-bi...=0&P=21267
Re: Colorado Surveillance Program for Chronic Wasting Disease
Transmission to Humans (TWO SUSPECT CASES)
lists.ifas.ufl.edu/cgi-bi...T=0&P=1165
Transmissible Mink Encephalopathy TME
transmissible-mink-enceph...gspot.com/
TME hyper/drowsy, INTER-SPECIES TRANSMISSION CWD and strain
properties
/www.blogger.com/comment....5153980667
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in
the United States
cjdusa.blogspot.com/
i am reminded of a few things deep throat (high ranking official at usda)
told me years ago;
==========================================
The most frightening thing I have read all day is the
report of Gambetti's finding of a new strain of
sporadic cjd in young people.........Dear God,
/www.blogger.com/comment....7128128100
BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA, A REVIEW OF SORTS
madcowtesting.blogspot.com/
MADCOW USDA the untold story
madcowusda.blogspot.com/
MADCOW USDA the untold story continued
/www.blogger.com/comment....1293855400
USA NOR-98 SCRAPIE UPDATE AUGUST 31, 2007 RISES TO 5 DOCUMENTED CASES
nor-98.blogspot.com/
Government Accountability Project
/www.blogger.com/comment....9213239559
PLEASE NOTE IN USA CJD UPDATE AS AT JUNE 2007, please note steady increase
in ''TYPE UNKNOWN''. ...TSS
1 Acquired in the United Kingdom; 2 Acquired in Saudi Arabia; 3 Includes 17
inconclusive and 9 pending (1 from 2006, 8
from 2007); 4 Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1
from 2001, 1 from 2003, 4 from 2004, 3
from 2005, 4 from 2006) and 36 type pending (2 from 2005, 8 from 2006,
*** 26 from 2007)
www.cjdsurveillance.com/p...-table.pdf
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
An Indiana hunter will be allowed to keep the head mount of a deer he killed in Wyoming that tested positive for chronic wasting disease.
The unidentified hunter knew about the CWD risk and submitted a portion of the animal to the Wyoming Game and Fish Department for testing before having the meat deboned for transport home. After the animal tested positive for CWD, Wyoming officials contacted the hunter and the Indiana Department of Natural Resources.
Indiana DNR officials disposed of the meat, but the hunter was allowed to keep the mount, according to Dr. Jennifer Strasser, a veterinarian with the Indiana Board of Animal Health and a state conservation officer.
"As long as the skull cap and cape are cleaned properly, the hunter can safely keep the mount," she said.
The Indiana DNR has tight restrictions on transporting deer, elk and other cervids into the state. For information go to www.in.gov/dnr/deerhealth/cwd.htm.
www.courier-journal.com/a...002/SPORTS
stupid is, as stupid does. ...forest gump
From: "Terry S. Singeltary Sr."
Subject: CWD UPDATE 88 AUGUST 31, 2007
lists.ifas.ufl.edu/cgi-bi...&T=0&P=450
Date: Wed, 29 Aug 2007 21:13:08 -0500
From: "Terry S. Singeltary Sr."
Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)
lists.ifas.ufl.edu/cgi-bi...=0&P=26079
Monitoring the Potential Transmission of Chronic Wasting Disease to Humans
Using a Hunter Registry Database in Wyoming (405 lines)
From: Terry S. Singeltary Sr.
Date: Thu, 30 Aug 2007 21:23:42 -0500
lists.ifas.ufl.edu/cgi-bi...S=&P=27654
Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease
creates a new prion strain
Date: August 25, 2007 at 12:42 pm PST
Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease
creates a new prion strain
Date: August 25, 2007 at 12:42 pm PST
J Biol Chem. 2007 Aug 20; : 17709374
Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a
new prion strain.
[My paper] Atsushi Kobayashi , Masahiro Asano , Shirou Mohri , Tetsuyuki
Kitamoto
The genotype (methionine or valine) at polymorphic codon 129 of the human
prion protein (PrP) gene and the type (type 1 or type 2) of abnormal isoform
of PrP (PrP(Sc)) are major determinants of the clinicopathological
phenotypes of sporadic Creutzfeldt-Jakob disease (sCJD). Here we found that
transmission of sCJD prions from a patient with valine homozygosity (129V/V)
and type 2 PrP(Sc) (sCJD-VV2 prions) to mice expressing human PrP with
methionine homozygosity (129M/M) generated unusual PrP(Sc) intermediate in
size between type 1 and type 2. The intermediate type PrP(Sc) was seen in
all examined dura mater graft-associated CJD cases with 129M/M and
plaque-type PrP deposits (p-dCJD). p-dCJD prions and sCJD-VV2 prions
exhibited similar transmissibility and neuropathology, and the identical
type of PrP(Sc) when inoculated into PrP-humanized mice with 129M/M or
129V/V. These findings suggest that p-dCJD could be caused by cross-sequence
transmission of sCJD-VV2 prions.
snip...
In this study, the strain-dependent traits of sCJDMM1
prions were inherited through cross-sequence
transmission without any modification. The
humanized mice with 129V/V produced type 1 PrPres
after inoculation with sCJD-MM1 prions. Because
sCJD-VV1 cases are extremely rare (at most 1-2%
of the total number of sCJD cases) and characterized
by early onset (mean age at onset: 39.3 years) (5),
####################################
our results raise the possibility that CJD cases
classified as VV1 may include cases caused by
iatrogenic transmission of sCJD-MM1 prions or
food-borne infection by type 1 prions from animals,
e.g., chronic wasting disease prions in cervid. In fact,
two CJD-VV1 patients who hunted deer or
consumed venison have been reported (40, 41). The
results of the present study emphasize the need for
traceback studies and careful re-examination of the
biochemical properties of sCJD-VV1 prions.
###################################
In conclusion, cross-sequence transmission of
sCJD-VV2 prions generates a new prion strain with
altered conformational properties and disease
phenotypes as p-dCJD prions. Furthermore, the
newly generated prions have unique transmissibility
including the traceback phenomenon. In the future, if
atypical prion strains emerge through cross-sequence
transmission, especially from animals, traceback
studies will enable us to identify the origin of the
prions.
REFERENCES...snip...end
FULL TEXT ;
www.jbc.org/cgi/content/a...type=HWCIT
lists.ifas.ufl.edu/cgi-bi...=0&P=21267
Re: Colorado Surveillance Program for Chronic Wasting Disease
Transmission to Humans (TWO SUSPECT CASES)
lists.ifas.ufl.edu/cgi-bi...T=0&P=1165
Transmissible Mink Encephalopathy TME
transmissible-mink-enceph...gspot.com/
TME hyper/drowsy, INTER-SPECIES TRANSMISSION CWD and strain
properties
/www.blogger.com/comment....5153980667
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in
the United States
cjdusa.blogspot.com/
i am reminded of a few things deep throat (high ranking official at usda)
told me years ago;
==========================================
The most frightening thing I have read all day is the
report of Gambetti's finding of a new strain of
sporadic cjd in young people.........Dear God,
/www.blogger.com/comment....7128128100
BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA, A REVIEW OF SORTS
madcowtesting.blogspot.com/
MADCOW USDA the untold story
madcowusda.blogspot.com/
MADCOW USDA the untold story continued
/www.blogger.com/comment....1293855400
USA NOR-98 SCRAPIE UPDATE AUGUST 31, 2007 RISES TO 5 DOCUMENTED CASES
nor-98.blogspot.com/
Government Accountability Project
/www.blogger.com/comment....9213239559
PLEASE NOTE IN USA CJD UPDATE AS AT JUNE 2007, please note steady increase
in ''TYPE UNKNOWN''. ...TSS
1 Acquired in the United Kingdom; 2 Acquired in Saudi Arabia; 3 Includes 17
inconclusive and 9 pending (1 from 2006, 8
from 2007); 4 Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1
from 2001, 1 from 2003, 4 from 2004, 3
from 2005, 4 from 2006) and 36 type pending (2 from 2005, 8 from 2006,
*** 26 from 2007)
www.cjdsurveillance.com/p...-table.pdf
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
